Description
GPRASP1 was isolated in a screen to identify proteins in micethat copurify with myostatin (GDF-8), a potent negative regulator of skeletalmuscle mass. The GPRASP1 cDNA encodes a 571amino acid protein that contains a 29 amino acid signal sequence and iscomprised of many conserved domains: WAP, follistatin/Kazal, immunoglobulin,two tandem Kunitz, and netrin. Two related human proteins which contain thesame domain structure are called WFIKKN (based on the presence and order ofthese conserved domains) and WFIKKNRP (WFIKKN-related protein)